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Phenotypes Associated with This Genotype
Genotype
MGI:6360065
Allelic
Composition		 Mir146tm1.1Lfl/Mir146tm1.1Lfl
Tg(CD2-icre)4Kio/0
Genetic
Background		 involves: C57BL/6 * C57BL/10 * CBA/Ca
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mir146tm1.1Lfl mutation (1 available); any Mir146 mutation (14 available)
Tg(CD2-icre)4Kio mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased germinal center B cell number ( J:266124 )
• following immunization with sheep red blood cells similar to in B cell conditional knock-outs
increased T follicular helper cell number ( J:266124 )
• following immunization with sheep red blood cells

hematopoietic system
increased germinal center B cell number ( J:266124 )
• following immunization with sheep red blood cells similar to in B cell conditional knock-outs
increased T follicular helper cell number ( J:266124 )
• following immunization with sheep red blood cells

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/06/2026
MGI 6.24 		The Jackson Laboratory