Phenotypes Associated with This Genotype

Genotype
MGI:6360060

• Allelic Composition: Mir146^tm1.1Lfl/Mir146^tm1.1Lfl; Tg(Cr2-cre)3Cgn/0
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased germinal center B cell number ( J:266124 )

• minimal in young un-immunized mice on GL7+PNA+, which is further exacerbated with age

• at 6 months of age in un-immunized mice

• in young mice immunized with sheep red blood cells

increased plasma cell number ( J:266124 )

• in young mice immunized with sheep red blood cells

increased T follicular helper cell number ( J:266124 )

• at 6 months of age in un-immunized mice

• in young mice immunized with sheep red blood cells

increased IgG level ( J:266124 )

• SRBC-specific in young mice immunized with sheep red blood cells (SRBC)

increased IgG1 level ( J:266124 )

• following immunization with 4-hydroxy-3-nitrophenyl linked to Keyhole Limpet Hemocyanin (KLH) (NP-KLH) in alum

increased anti-double stranded DNA antibody level ( J:266124 )

• at 6 months of age in un-immunized mice

hematopoietic system

increased germinal center B cell number ( J:266124 )

• minimal in young un-immunized mice on GL7+PNA+, which is further exacerbated with age

• at 6 months of age in un-immunized mice

• in young mice immunized with sheep red blood cells

increased plasma cell number ( J:266124 )

• in young mice immunized with sheep red blood cells

increased T follicular helper cell number ( J:266124 )

• at 6 months of age in un-immunized mice

• in young mice immunized with sheep red blood cells

increased IgG level ( J:266124 )

• SRBC-specific in young mice immunized with sheep red blood cells (SRBC)

increased IgG1 level ( J:266124 )

• following immunization with 4-hydroxy-3-nitrophenyl linked to Keyhole Limpet Hemocyanin (KLH) (NP-KLH) in alum