Phenotypes Associated with This Genotype

Genotype
MGI:6359753

• Allelic Composition: Baiap2^Gt(XG757)Byg/Baiap2^Gt(XG757)Byg; Baiap2l1^tm1.1Arte/Baiap2l1^tm1.1Arte
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * C57BL/6NTac

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

perinatal lethality, complete penetrance ( J:275147 )

• non-resorbed embryos are detected in only 1 out of 10 litters analyzed at E18.8

• no double homozygotes are recovered at weaning

lethality throughout fetal growth and development, incomplete penetrance ( J:275147 )

• only 2.7% of double homozygotes are recovered at E18.5

embryonic lethality during organogenesis, incomplete penetrance ( J:275147 )

• although double homozygotes are present at normal Mendelian ratios at E10.5, reduced numbers are detected at E14.5

integument

subcutaneous edema ( J:275147 )

• at E14.5, almost all (14 of 15) double homozygotes show severe subcutaneous edema

cardiovascular system

cardiovascular system phenotype ( J:275147 )

N • in vitro angiogenesis of E14.5 umbilical arterial explants in response to VEGF signals is normal

abnormal placental labyrinth vasculature morphology ( J:275147 )

• at E14.5, vessel density of double homozygotes is only ~50% of wild-type and, more significantly, 30% less than that in single Baiap2^Gt(XG757)Byg homozygotes

• average lumen size of CD31+ blood vessels is ~12.4% larger than that in single Baiap2^Gt(XG757)Byg homozygotes

abnormal heart development ( J:275147 )

• at E14.5, double homozygotes exhibit early cardiac defects similar to those observed in single Baiap2^Gt(XG757)Byg homozygotes

abnormal heart tube morphology ( J:275147 )

• at E10.5, double homozygotes display heart tube malformations

abnormal interventricular septum morphology ( J:275147 )

• at E14.5, double homozygotes show incomplete IVS closure

abnormal interventricular septum membranous part morphology ( J:275147 )

• at E14.5, double homozygotes show malformation of the mesenchymal membranous part of the septa

abnormal heart right ventricle morphology ( J:275147 )

• at E14.5, the heart right ventricles are misshapen

pericardial edema ( J:275147 )

• at E10.5, double homozygotes exhibit pericardial edema with similar ratios as single Baiap2^Gt(XG757)Byg homozygotes

embryo

abnormal placental labyrinth vasculature morphology ( J:275147 )

• at E14.5, vessel density of double homozygotes is only ~50% of wild-type and, more significantly, 30% less than that in single Baiap2^Gt(XG757)Byg homozygotes

• average lumen size of CD31+ blood vessels is ~12.4% larger than that in single Baiap2^Gt(XG757)Byg homozygotes

abnormal trophoblast giant cell morphology ( J:275147 )

• at E14.5, patches of trophoblast giant cells are observed in the spongiotrophoblast layer

abnormal spongiotrophoblast layer morphology ( J:275147 )

• at E14.5, placentas exhibit a much thinner and significantly more disorganized Tpbpa+ spongiotrophoblast layer than that in single Baiap2^Gt(XG757)Byg homozygotes

homeostasis/metabolism

pericardial edema ( J:275147 )

• at E10.5, double homozygotes exhibit pericardial edema with similar ratios as single Baiap2^Gt(XG757)Byg homozygotes

subcutaneous edema ( J:275147 )

• at E14.5, almost all (14 of 15) double homozygotes show severe subcutaneous edema

limbs/digits/tail

forelimb oligodactyly ( J:275147 )

• at E14.5, almost all (13 of 15) double homozygotes show forepaw oligodactyly; loss of posterior digits in the right forepaw is observed