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Phenotypes Associated with This Genotype
Genotype
MGI:6358832
Allelic
Composition
Mast1em1Dak/Mast1+
Genetic
Background
B6.Cg-Mast1em1Dak
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mast1em1Dak mutation (0 available); any Mast1 mutation (51 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• increase in neuronal apoptosis in the P0 cortex, with apoptosis more severe in the caudal regions of the cortex
• large increase in neuronal apoptosis in the P0 cerebellum
• however, apoptosis levels in the cortex are similar to wild-type at P10 and 8 weeks of age
• thicker corpus callosum, with thickening most prominent in the rostral regions encompassing the genu and the mid-body
• increase in corpus callosum volume
• however, no difference in either myelin thickness or axonal caliber in the corpus callosum are seen
• caudal cortex is thinner at P10 with overall reduction in cortical volume and thickness, most pronounced in caudal regions
• significant reduction in the thickness of layer 5
• the granule cell layer appears thinner
• reduction in the total number of granule cells per section
• the molecular cell layer appears thinner
• severe reduction of the cerebellum
• however, foliation and lamination of the cerebellum are normal
• increase in the number of myelinated axons that project to the contralateral hemisphere

cellular
• increase in neuronal apoptosis in the P0 cortex, with apoptosis more severe in the caudal regions of the cortex
• large increase in neuronal apoptosis in the P0 cerebellum
• however, apoptosis levels in the cortex are similar to wild-type at P10 and 8 weeks of age


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/10/2022
MGI 6.19
The Jackson Laboratory