Phenotypes for Orai2 Tg(Cma1-cre)#Roer MGI:6358682 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Orai2^tm1.1Itl/Orai2^tm1.1Itl Tg(Cma1-cre)#Roer/0
Genetic Background	involves: 129S4/SvJaeSor * C57BL/6 * C57BL/6N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Orai2^tm1.1Itl mutation (0 available); any Orai2 mutation (13 available)
Tg(Cma1-cre)#Roer mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

increased susceptibility to type I hypersensitivity reaction ( J:278536 )

• mice sensitized with anti-DNP IgE and then treated with a solution containing DNP-HSA to induce passive systemic anaphylactic reaction show exacerbated anaphylaxis compared to controls, with mice showing delayed body temperature recovery

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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