Phenotypes Associated with This Genotype

Genotype
MGI:6358496

• Allelic Composition: Morrbid^em1Flv/Morrbid^em1Flv
• Genetic Background: C57BL/6N-Morrbid^em1Flv

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to bacterial infection induced morbidity/mortality ( J:236609 )

• in mice infected with Listeria monocytogenes

immune system

immune system phenotype ( J:236609 )

N • mice exhibit normal eosinophil, neutrophil and monocyte progenitors

abnormal myelopoiesis ( J:236609 )

• reduced short-lived myeloid cells in mixed bone marrow chimeras

decreased eosinophil cell number ( J:236609 )

• in the blood and tissue

decreased neutrophil cell number ( J:236609 )

• in the blood and tissue

decreased Ly6C high monocyte number ( J:236609 )

• in the blood and tissue

decreased Ly6C low monocyte number ( J:236609 )

• in blood

abnormal leukocyte physiology ( J:236609 )

• increased apoptosis of monocytes in bone marrow cultured ex vivo

abnormal eosinophil physiology ( J:236609 )

• increased apoptosis in bone marrow cultured ex vivo and in vitro bone marrow-derived eosinophils

abnormal neutrophil physiology ( J:236609 )

• increased apoptosis in bone marrow cultured ex vivo

increased susceptibility to bacterial infection ( J:236609 )

• mice infected with Listeria monocytogenes exhibit increased mortality, body weight loss and colony forming units in the spleen and liver compared with wild-type mice

increased susceptibility to bacterial infection induced morbidity/mortality ( J:236609 )

• in mice infected with Listeria monocytogenes

hematopoietic system

abnormal myelopoiesis ( J:236609 )

• reduced short-lived myeloid cells in mixed bone marrow chimeras

decreased eosinophil cell number ( J:236609 )

• in the blood and tissue

decreased neutrophil cell number ( J:236609 )

• in the blood and tissue

decreased Ly6C high monocyte number ( J:236609 )

• in the blood and tissue

decreased Ly6C low monocyte number ( J:236609 )

• in blood

abnormal leukocyte physiology ( J:236609 )

• increased apoptosis of monocytes in bone marrow cultured ex vivo

abnormal eosinophil physiology ( J:236609 )

• increased apoptosis in bone marrow cultured ex vivo and in vitro bone marrow-derived eosinophils

abnormal neutrophil physiology ( J:236609 )

• increased apoptosis in bone marrow cultured ex vivo