Phenotypes Associated with This Genotype

Genotype
MGI:6358254

• Allelic Composition: Knl1^{tm1c(EUCOMM)Hmgu}/Knl1^{tm1c(EUCOMM)Hmgu}; Trp53^tm1Brn/Trp53^tm1Brn; Tg(GFAP-cre)25Mes/0
• Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6N * FVB/N
• Cell Lines: HEPD0665_2_E05

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:278483 )

nervous system

nervous system phenotype ( J:278483 )

N • neuron loss is rescued by conditional knock-out of Trp53

telencephalon hypoplasia ( J:278483 )

• partially rescued by conditional knock-out of Trp53

cellular

aneuploidy ( J:278483 )

increased apoptosis ( J:278483 )

• partial rescue of apoptosis and DNA damage by conditional knock-out of Trp53

growth/size/body

microcephaly ( J:278483 )

• partially rescued by conditional knock-out of Trp53