Analysis Tools
mortality/aging
nervous system
microgliosis
(
J:278483
)
|
• mis-segregated chromosomes with DNA bridges located at the cleavage furrow
• however, karyotypes are normal
|
|
• neural progenitor cells prematurely exhibit the cell cycle and become migratory
|
|
• at E15.5 and E16.5 with some precursor cells located outside the ventricular zone and subventricular zone
|
|
• POU3F2-expressing L2-5 neurons
• CUX1-expressing L2-4 neurons
• due to increased apoptosis
• however, deep layer neuron numbers are normal
|
cellular
microgliosis
(
J:278483
)
|
• mis-segregated chromosomes with DNA bridges located at the cleavage furrow
• however, karyotypes are normal
|
|
• mis-segregated chromosomes with DNA bridges located at the cleavage furrow
• however, karyotypes are normal
|
|
• in the cortex at E15.5, abundant in the germinal zones and intermediate zone
• marginally by E17.5
• associated with increased DNA damage determined by gammaH2AX staining
• however, apoptotic cells are largely absent from the cortical plate
|
|
• neural progenitor cells prematurely exhibit the cell cycle and become migratory
|
|
• increased DSB repair
|
growth/size/body
microcephaly
(
J:278483
)
|
• less severe than in mice with the conditional activated by Emx1tm1(cre)Krj
|
homeostasis/metabolism
|
• increased DSB repair
|
immune system
microgliosis
(
J:278483
)
|
• mis-segregated chromosomes with DNA bridges located at the cleavage furrow
• however, karyotypes are normal
|
hematopoietic system
microgliosis
(
J:278483
)
|
• mis-segregated chromosomes with DNA bridges located at the cleavage furrow
• however, karyotypes are normal
|
