Phenotypes Associated with This Genotype

Genotype
MGI:6358216

• Allelic Composition: Zpld1^sprl/Zpld1^sprl
• Genetic Background: B6(129S4)-Zpld1^sprl/Kjn

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal vestibuloocular reflex ( J:278455 )

• a significant reduction in vestibulo-occular gain is found in homozygotes but not heterozygotes and homozygotes are more severely impaired than are cwh homozygotes

hyperactivity ( J:278455 )

circling ( J:278455 )

• approximately half of sprl homozygotes circle whereas all mice homozygous for the cwh allele circle and homozygotes for a null allele were not found to circle

hearing/vestibular/ear

hearing/vestibular/ear phenotype ( J:278455 )

N • normal ABR thresholds and vestibular sensory evoked potentials, normal appearing cochlea and otoconia in both the saccule and utricle, and intact otoconial membranes despite the vestibular dysfunction

abnormal vestibular system physiology ( J:278455 )

abnormal vestibuloocular reflex ( J:278455 )

• a significant reduction in vestibulo-occular gain is found in homozygotes but not heterozygotes and homozygotes are more severely impaired than are cwh homozygotes