Phenotypes Associated with This Genotype

Genotype
MGI:6358010

• Allelic Composition: Fryl^{tm1b(KOMP)Wtsi}/Fryl^{tm1b(KOMP)Wtsi}
• Genetic Background: C57BL/6N-Fryl^{tm1b(KOMP)Wtsi}/Wtsi
• Cell Lines: EPD0553_3_A01

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

lethality throughout fetal growth and development, incomplete penetrance ( J:261316 )

• fewer than the expected number of fetuses are seen at E14.5, indicating sub-viability at this time

embryo

placenta hemorrhage ( J:261316 )

• hemorrhagic areas/blood pools are seen in the E14.5 placenta

abnormal placenta morphology ( J:261316 )

• reduced cellular density of placenta at E14.5

• fibrotic/necrotic areas in the placenta at E14.5

abnormal placental labyrinth vasculature morphology ( J:261316 )

• labyrinth vascular defect at E14.5

small placenta ( J:261316 )

• small placenta at E14.5

placenta necrosis ( J:261316 )

• necrotic areas in the placenta at E14.5

cardiovascular system

abnormal placental labyrinth vasculature morphology ( J:261316 )

• labyrinth vascular defect at E14.5

placenta hemorrhage ( J:261316 )

• hemorrhagic areas/blood pools are seen in the E14.5 placenta