Phenotypes Associated with This Genotype

Genotype
MGI:6332960

• Allelic Composition: Sgce^{Gt(148G1)Cmhd}/Sgce⁺
• Genetic Background: B6.129-Sgce^{Gt(148G1)Cmhd}

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:251780 )

N • no evidence of myoclonus or limb dystonia is seen from the early postnatal period through 1.5 years of age when the allele is paternally inherited

N • myoclonus is not seen in response to audiogenic or tactile stimuli

abnormal behavior ( J:251780 )

• preweaning mice exhibit occasional stimulus-induced appendicular flexion posturing when the allele is inherited paternally

increased anxiety-related response ( J:251780 )

• males and females exhibit lower scores on the cross-maze test when the allele is inherited paternally

impaired coordination ( J:251780 )

• mice show more slips on the 9-mm round beam and the 9-mm square beam than wild-type mice when the allele is inherited paternally

• however, mice show normal behavior on the rotarod

abnormal gait ( J:251780 )

• preweaning mice exhibit tiptoe walking when the allele is inherited paternally

• males and females with the paternally inherited allele exhibit higher scores on the rating scale for abnormal movements

• males exhibit higher forepaw and hindpaw stride frequencies when the allele is inherited paternally

• hindpaw stance width is narrower when the allele is inherited paternally

short stride length ( J:251780 )

♂ • males exhibit shorter forepaw and hindpaw stride lengths when the allele is inherited paternally

decreased locomotor activity ( J:251780 )

• mice are less active on multiple parameters of the open-field activity when the allele is inherited paternally, with females showing a greater decrease in activity than males

growth/size/body

decreased body size ( J:251780 )

• mice at 10-15% smaller when the allele is inherited paternally

homeostasis/metabolism

increased noradrenaline level ( J:251780 )

• noradrenaline levels trend higher when the allele is inherited paternally

• however, monoamine levels are normal