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Phenotypes Associated with This Genotype
Genotype
MGI:6316681
Allelic
Composition
Nphs2tm2.1Antc/Nphs2tm3.1Antc
Tg(CAG-cre/Esr1*)86Lbgn/0
Genetic
Background
involves: 129S2/SvPas * C57BL/6 * DBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nphs2tm2.1Antc mutation (0 available); any Nphs2 mutation (22 available)
Nphs2tm3.1Antc mutation (0 available); any Nphs2 mutation (22 available)
Tg(CAG-cre/Esr1*)86Lbgn mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Nphs2tm2.1Antc/Nphs2tm3.1Antc Tg(CAG-cre/Esr1*)86Lbgn/0 mice develop focal-segmental glomerulosclerosis

mortality/aging
• the median survival of tamoxifen-treated mice is 12 weeks

growth/size/body
• mice exhibit lower body weight from week 6 onward after tamoxifen treatment

cardiovascular system
• blood pressure moderately increases after tamoxifen treatment

homeostasis/metabolism
• mice exhibit increased creatinine levels within a few days of tamoxifen treatment
• mice exhibit hypercholesterolemia 4 weeks after tamoxifen induction
• mice exhibit hypoalbuminemia 4 weeks after tamoxifen induction
• mice develop proteinuria within a few days of tamoxifen treatment which increases to a maximum 4-5 weeks after induction and thereafter decreases gradually but remains elevated compared to controls

renal/urinary system
• mice exhibit increased creatinine levels within a few days of tamoxifen treatment
• mice develop proteinuria within a few days of tamoxifen treatment which increases to a maximum 4-5 weeks after induction and thereafter decreases gradually but remains elevated compared to controls
• foot processes are irregularly shaped one week after tamoxifen induction, progressing to effacement
• foot processes are fused one week after tamoxifen induction progressing to global fusion and effacement
• in tamoxifen treated mice
• mice show reduced podocyte number per glomerulus starting at the end of the second week after tamoxifen induction (68% of controls) to 18% of controls at 12-16 weeks
• glomerular basement membrane is thickened in tamoxifen-induced mice
• mice exhibit early glomerular sclerosis form the first week after tamoxifen induction that progresses increases until week eight when 100% of glomeruli are partially or globally sclerosed
• mice develop severe interstitial fibrosis which is visible from the first week after tamoxifen induction and increase to 12% of the total kidney area in the course of the disease
• mice develop tubular atrophy that is visible from the first week after tamoxifen induction
• mice exhibit diminished creatinine clearance 4 weeks after tamoxifen induction
• mice progress to renal failure after tamoxifen-induction

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
nephrotic syndrome DOID:1184 J:245693


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/22/2022
MGI 6.21
The Jackson Laboratory