Phenotypes Associated with This Genotype

Genotype
MGI:6315920

• Allelic Composition: Dffb^tm1Osa/Dffb^tm1Osa
• Genetic Background: B6.129-Dffb^tm1Osa

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

decreased response of heart to induced stress ( J:259377 )

• the myocardial hypertrophic response is blocked in mice after 8 weeks of aortic banding, with the ratios of heart weight/body weight heart weight/tibia length, and lung weight/body weight decreased, improved cardiac dilation and reduced cardiac dysfunction, ran reduced cardiac fibrotic response compared to controls, indicating suppressed pressure overload-induced cardiac remodeling

• the number of apoptotic cells is decreased in myocardial tissue is decreased in mice subjected to aortic banding

homeostasis/metabolism

decreased response of heart to induced stress ( J:259377 )

• the myocardial hypertrophic response is blocked in mice after 8 weeks of aortic banding, with the ratios of heart weight/body weight heart weight/tibia length, and lung weight/body weight decreased, improved cardiac dilation and reduced cardiac dysfunction, ran reduced cardiac fibrotic response compared to controls, indicating suppressed pressure overload-induced cardiac remodeling

• the number of apoptotic cells is decreased in myocardial tissue is decreased in mice subjected to aortic banding