Analysis Tools
cellular
|
• mouse embryonic fibroblasts (MEFs) show fewer cells that are ciliated compared to controls MEFs
• mean cilia length is reduced in MEFs
• however, overall structure of cilia in neural tube sections from E10.5 embryos is normal
|
growth/size/body
|
• variable penetrance of polycystic kidney by 6 months of age
|
nervous system
hydrocephaly
(
J:269515
)
|
• variable penetrance of hydrocephalus by 6 months of age
• however, neural patterning in E10.5 embryos is similar to heterozygous controls
|
renal/urinary system
|
• variable penetrance of polycystic kidney by 6 months of age
|
