Phenotypes Associated with This Genotype

Genotype
MGI:6305379

• Allelic Composition: Dock2^m15Btlr/Dock2^m15Btlr
• Genetic Background: C57BL/6J-Dock2^m15Btlr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased B-1 B cell number ( J:274942 )

• increased frequencies of B1 cells in the peripheral blood

decreased B cell number ( J:274942 )

• reduced frequencies of B cells in the peripheral blood

increased NK cell number ( J:274942 )

• increased frequencies of NK cells in the peripheral blood

decreased CD8-positive, naive alpha-beta T cell number ( J:274942 )

• reduced frequencies of nave CD8 T cells in CD8 T cells in the peripheral blood

increased CD8-positive, alpha-beta T cell number ( J:274942 )

• increased frequencies of CD8+ T cells and CD8+ T cells in CD3+ T cells in the peripheral blood

increased central memory CD8 positive, alpha-beta T cell number ( J:274942 )

• increased frequencies of central memory CD8 T cells in CD8 T cells in the peripheral blood

decreased T cell number ( J:274942 )

• reduced frequencies of T cells in the peripheral blood

decreased CD4-positive, alpha-beta T cell number ( J:274942 )

• reduced frequencies of CD4+ T cells and CD4+ T cells in CD3+ T cells in the peripheral blood

hematopoietic system

increased B-1 B cell number ( J:274942 )

• increased frequencies of B1 cells in the peripheral blood

decreased B cell number ( J:274942 )

• reduced frequencies of B cells in the peripheral blood

increased NK cell number ( J:274942 )

• increased frequencies of NK cells in the peripheral blood

decreased CD8-positive, naive alpha-beta T cell number ( J:274942 )

• reduced frequencies of nave CD8 T cells in CD8 T cells in the peripheral blood

increased CD8-positive, alpha-beta T cell number ( J:274942 )

• increased frequencies of CD8+ T cells and CD8+ T cells in CD3+ T cells in the peripheral blood

increased central memory CD8 positive, alpha-beta T cell number ( J:274942 )

• increased frequencies of central memory CD8 T cells in CD8 T cells in the peripheral blood

decreased T cell number ( J:274942 )

• reduced frequencies of T cells in the peripheral blood

decreased CD4-positive, alpha-beta T cell number ( J:274942 )

• reduced frequencies of CD4+ T cells and CD4+ T cells in CD3+ T cells in the peripheral blood