Phenotypes Associated with This Genotype

Genotype
MGI:6305323

• Allelic Composition: Stat1^m5Btlr/Stat1^m5Btlr
• Genetic Background: C57BL/6J-Stat1^m5Btlr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal T cell differentiation ( J:274938 )

• increased CD44 expression on peripheral blood T cells

abnormal CD4-positive T cell differentiation ( J:274938 )

• increased CD44 expression on peripheral blood CD4 T cells

abnormal CD8-positive, alpha-beta T cell differentiation ( J:274938 )

• increased CD44 expression on peripheral blood CD8 T cells

decreased CD8-positive, naive alpha-beta T cell number ( J:274938 )

• reduced frequencies of nave CD8 T cells in CD8 T cells in the peripheral blood

increased T cell number ( J:274938 )

• increased frequencies of CD44+ T cells in the peripheral blood

increased CD4-positive, alpha-beta T cell number ( J:274938 )

• increased frequencies of CD44+ CD4 T cells in the peripheral blood

increased effector memory CD4-positive, alpha-beta T cell number ( J:274938 )

• increased frequencies of effector memory CD4 T cells in CD4 T cells in the peripheral blood

increased effector memory CD8-positive, alpha-beta T cell number ( J:274938 )

• increased frequencies of effector memory CD8 T cells in CD8 T cells in the peripheral blood

decreased cytotoxic T cell cytolysis ( J:274938 )

• decreased killing of CTL targets pulsed with a MHC-class I restrictedpeptide for beta-galactosidase after immunization with rSFV-beta-galactosidase

hematopoietic system

abnormal T cell differentiation ( J:274938 )

• increased CD44 expression on peripheral blood T cells

abnormal CD4-positive T cell differentiation ( J:274938 )

• increased CD44 expression on peripheral blood CD4 T cells

abnormal CD8-positive, alpha-beta T cell differentiation ( J:274938 )

• increased CD44 expression on peripheral blood CD8 T cells

decreased CD8-positive, naive alpha-beta T cell number ( J:274938 )

• reduced frequencies of nave CD8 T cells in CD8 T cells in the peripheral blood

increased T cell number ( J:274938 )

• increased frequencies of CD44+ T cells in the peripheral blood

increased CD4-positive, alpha-beta T cell number ( J:274938 )

• increased frequencies of CD44+ CD4 T cells in the peripheral blood

increased effector memory CD4-positive, alpha-beta T cell number ( J:274938 )

• increased frequencies of effector memory CD4 T cells in CD4 T cells in the peripheral blood

increased effector memory CD8-positive, alpha-beta T cell number ( J:274938 )

• increased frequencies of effector memory CD8 T cells in CD8 T cells in the peripheral blood

decreased cytotoxic T cell cytolysis ( J:274938 )

• decreased killing of CTL targets pulsed with a MHC-class I restrictedpeptide for beta-galactosidase after immunization with rSFV-beta-galactosidase