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Phenotypes Associated with This Genotype
Genotype
MGI:6305084
Allelic
Composition
Tg(MECP2)1Hzo/0
Genetic
Background
FVB-Tg(MECP2)1Hzo/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(MECP2)1Hzo mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
• V1 neurons show age-dependent change in firing rate, with higher evoked responses at 8 weeks but lower at 14 weeks and lower firing rates to low and high spatial frequencies in 14 week old V1 neurons
• primary visual cortex (V1) neurons show a preference for higher spatial frequencies at 8 and 14 weeks of age indicating higher visual acuity
• in a two-alternative forced choice visual detection task, mice exhibit higher behavioral performance in spatial frequency detection
• V1 neurons show age-dependent (at 8 weeks but not 14 weeks of age) change in contrast sensitivity, indicating higher contrast sensitivity
• behavioral performance in visual detection of stimuli that varies in contrast shows improved performance in detecting low contrasts

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
syndromic X-linked intellectual disability Lubs type DOID:0060799 OMIM:300260
J:253720


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/12/2019
MGI 6.14
The Jackson Laboratory