Phenotypes Associated with This Genotype

Genotype
MGI:6304445

• Allelic Composition: Cd8b1^m2Btlr/Cd8b1^m2Btlr
• Genetic Background: C57BL/6J-Cd8b1^m2Btlr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal B cell differentiation ( J:274761 )

• expression of B220 on peripheral B cells was reduced

• increase in the peripheral blood B to T cell ratio

abnormal CD8-positive, alpha-beta T cell differentiation ( J:274761 )

• the expression of CD44 on CD8+T cells was increased

• increase in the peripheral blood CD4+to CD8+T cell ratio

increased CD4-positive, alpha-beta T cell number ( J:274761 )

• increased frequencies of CD4+T cells and CD4+T cells in CD3+T cells in the peripheral blood

increased central memory CD8 positive, alpha-beta T cell number ( J:274761 )

• increased frequencies of central memory CD8 T cells in CD8 T cells in the peripheral blood

increased effector memory CD8-positive, alpha-beta T cell number ( J:274761 )

• increased frequencies of effector memory CD8 T cells in CD8 T cells in the peripheral blood

decreased CD8-positive, naive alpha-beta T cell number ( J:274761 )

• reduced frequencies of naive CD8 T cells in CD8 T cells in the peripheral blood

decreased T cell number ( J:274761 )

• reduced frequencies of T cells in the peripheral blood

decreased CD8-positive, alpha-beta T cell number ( J:274761 )

• reduced frequencies of CD8+T cells, CD8+T cells in CD3+T cells, and CD44+CD8 T cells in the peripheral blood

hematopoietic system

abnormal B cell differentiation ( J:274761 )

• expression of B220 on peripheral B cells was reduced

• increase in the peripheral blood B to T cell ratio

abnormal CD8-positive, alpha-beta T cell differentiation ( J:274761 )

• the expression of CD44 on CD8+T cells was increased

• increase in the peripheral blood CD4+to CD8+T cell ratio

increased CD4-positive, alpha-beta T cell number ( J:274761 )

• increased frequencies of CD4+T cells and CD4+T cells in CD3+T cells in the peripheral blood

increased central memory CD8 positive, alpha-beta T cell number ( J:274761 )

• increased frequencies of central memory CD8 T cells in CD8 T cells in the peripheral blood

increased effector memory CD8-positive, alpha-beta T cell number ( J:274761 )

• increased frequencies of effector memory CD8 T cells in CD8 T cells in the peripheral blood

decreased CD8-positive, naive alpha-beta T cell number ( J:274761 )

• reduced frequencies of naive CD8 T cells in CD8 T cells in the peripheral blood

decreased T cell number ( J:274761 )

• reduced frequencies of T cells in the peripheral blood

decreased CD8-positive, alpha-beta T cell number ( J:274761 )

• reduced frequencies of CD8+T cells, CD8+T cells in CD3+T cells, and CD44+CD8 T cells in the peripheral blood