Phenotypes Associated with This Genotype

Genotype
MGI:6303794

• Allelic Composition: Notum^{Gt(OST172035)Lex}/Notum^{Gt(OST172035)Lex}
• Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

adipose tissue

decreased body fat mass ( J:274615 )

mortality/aging

postnatal lethality, incomplete penetrance ( J:266040 )

• fewer than expected mice at 2 weeks of age

• however, survival after 2 weeks is normal

hematopoietic system

anemia ( J:274615 )

• mild

increased leukocyte cell number ( J:274615 )

craniofacial

dental pulp necrosis ( J:266040 )

• in all molar of aged mice

abnormal molar morphology ( J:274615 )

abnormal molar root morphology ( J:266040 )

• shorter, thinner and more irregular in shape than in wild-type mice

abnormal periodontal ligament morphology ( J:266040 )

• in aged mice with irregular thickened bands of collagen

abnormal cementum morphology ( J:266040 )

• irregular aggregation of dysplastic cementum covering outer surfaces of molar roots

abnormal dentin morphology ( J:274615 )

abnormal dentin development ( J:266040 )

• all mice exhibit thin mantle dentin on both molar and incisor (lingual and labial quadrant) teeth with disorganized and atubular underlying dentin compared with wild-type mice

• however, lateral and medial quadrant incisor dentin is normal

abnormal odontoblast morphology ( J:266040 )

• entrapped at the lingual and labial quadrants of incisors

carious teeth ( J:266040 )

• of molars; widespread in aged mice

apical tooth abscess ( J:266040 )

• suppurative inflammation with periapical abscesses in older mice

limbs/digits/tail

increased femur compact bone thickness ( J:274615 )

• in female and male mice at 16 weeks without further increase through one year age

• with increased bone area, polar moment of inertia and bone strength

• however, trabecular bone volume to trabecular volume in vertebrae and total bone area are normal

renal/urinary system

increased kidney weight ( J:266040 )

• in mice with one kidney

single kidney ( J:266040 )

• either left or right in 23 of 89 mice

immune system

increased leukocyte cell number ( J:274615 )

chronic inflammation ( J:274615 )

• mild

periodontium inflammation ( J:266040 )

• mild to moderate in young mice restricted to teeth and roots with necrotic pulp

• in all molar teeth of older mice

• suppurative inflammation with periapical abscesses in older mice

growth/size/body

decreased body fat mass ( J:274615 )

dental pulp necrosis ( J:266040 )

• in all molar of aged mice

abnormal molar morphology ( J:274615 )

abnormal molar root morphology ( J:266040 )

• shorter, thinner and more irregular in shape than in wild-type mice

abnormal periodontal ligament morphology ( J:266040 )

• in aged mice with irregular thickened bands of collagen

abnormal cementum morphology ( J:266040 )

• irregular aggregation of dysplastic cementum covering outer surfaces of molar roots

abnormal dentin morphology ( J:274615 )

abnormal dentin development ( J:266040 )

• all mice exhibit thin mantle dentin on both molar and incisor (lingual and labial quadrant) teeth with disorganized and atubular underlying dentin compared with wild-type mice

• however, lateral and medial quadrant incisor dentin is normal

abnormal odontoblast morphology ( J:266040 )

• entrapped at the lingual and labial quadrants of incisors

carious teeth ( J:266040 )

• of molars; widespread in aged mice

apical tooth abscess ( J:266040 )

• suppurative inflammation with periapical abscesses in older mice

decreased lean body mass ( J:274615 )

increased lean body mass ( J:266040 )

• with increasing age

decreased body weight ( J:274615 )

• slightly

increased kidney weight ( J:266040 )

• in mice with one kidney

skeleton

skeleton phenotype ( J:274615 )

N • mice exhibit normal femur length and LV5 trabecular bone volume to trabecular volume

dental pulp necrosis ( J:266040 )

• in all molar of aged mice

abnormal molar morphology ( J:274615 )

abnormal molar root morphology ( J:266040 )

• shorter, thinner and more irregular in shape than in wild-type mice

abnormal periodontal ligament morphology ( J:266040 )

• in aged mice with irregular thickened bands of collagen

abnormal cementum morphology ( J:266040 )

• irregular aggregation of dysplastic cementum covering outer surfaces of molar roots

abnormal dentin morphology ( J:274615 )

abnormal dentin development ( J:266040 )

• all mice exhibit thin mantle dentin on both molar and incisor (lingual and labial quadrant) teeth with disorganized and atubular underlying dentin compared with wild-type mice

• however, lateral and medial quadrant incisor dentin is normal

abnormal odontoblast morphology ( J:266040 )

• entrapped at the lingual and labial quadrants of incisors

carious teeth ( J:266040 )

• of molars; widespread in aged mice

apical tooth abscess ( J:266040 )

• suppurative inflammation with periapical abscesses in older mice

increased bone mineral density ( J:274615 )

• in female and male

increased compact bone thickness ( J:274615 )

• of femur, tibia, humerus, radius, pelvis and femoral neck of female and male mice

• in mice following post-pubertal ovariectomy-induced bone loss

increased femur compact bone thickness ( J:274615 )

• in female and male mice at 16 weeks without further increase through one year age

• with increased bone area, polar moment of inertia and bone strength

• however, trabecular bone volume to trabecular volume in vertebrae and total bone area are normal

increased bone strength ( J:274615 )