Phenotypes Associated with This Genotype

Genotype
MGI:6303767

• Allelic Composition: Bdh1^{tm1c(EUCOMM)Wtsi}/Bdh1^{tm1c(EUCOMM)Wtsi}; Tg(Myh6-cre)2182Mds/0
• Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:274475 )

• slightly fewer than expected mice are present at weaning

cardiovascular system

abnormal heart left ventricle morphology ( J:274475 )

• fasted mice exhibit increased left ventricular internal diameter and volume compared with control mice

• however, mice exhibit normal cardiac phenotype under basal conditions

decreased heart left ventricle muscle contractility ( J:274475 )

• fasted mice exhibit reduced left ventricular fractional shortening and longitudinal strain rate compared with control mice

• 4 weeks after pressure overload induced by transverse aortic constriction combined with a small apical myocardial infarction (TAC/MI), mice exhibit more severe left ventricle dysfunction including lower left ventricle ejection fraction and greater left ventricle end-diastolic volume and end-systolic volume compared with control mice

muscle

decreased heart left ventricle muscle contractility ( J:274475 )

• fasted mice exhibit reduced left ventricular fractional shortening and longitudinal strain rate compared with control mice

• 4 weeks after pressure overload induced by transverse aortic constriction combined with a small apical myocardial infarction (TAC/MI), mice exhibit more severe left ventricle dysfunction including lower left ventricle ejection fraction and greater left ventricle end-diastolic volume and end-systolic volume compared with control mice