Phenotypes Associated with This Genotype

Genotype
MGI:6303639

• Allelic Composition: Atp6v0a2^tm1Kdb/Atp6v0a2^tm1Kdb; Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺
• Genetic Background: involves: C57BL/6 * C57BL/10 * CBA/Ca

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

decreased T cell number ( J:274048 )

• population of lymphoid cells in spleen is severely diminished

• total T cells are reduced 4.8-fold and 16.6-fold in spleen and blood, respectively

decreased alpha-beta T cell number ( J:274048 )

• only the alpha-beta T cells, not the gamma-delta T cells, are diminished in the spleen and blood

• the alpha-beta T cell percentage is reduced 6.23-fold and cell number is reduced 21-fold in the spleen

• similar reductions in alpha-beta T cells is seen in the thymus and bone marrow

decreased CD4-positive, alpha-beta T cell number ( J:274048 )

• percentage of CD4+ T helper cells is reduced 25.71-fold in the spleen and 58.3-fold in the blood

abnormal CD8-positive, alpha-beta cytotoxic T cell morphology ( J:274048 )

• percentage of CD8+ cytotoxic T cells is reduced 13.73-fold in the spleen and 11.16-fold in the blood

immune system

decreased T cell number ( J:274048 )

• population of lymphoid cells in spleen is severely diminished

• total T cells are reduced 4.8-fold and 16.6-fold in spleen and blood, respectively

decreased alpha-beta T cell number ( J:274048 )

• only the alpha-beta T cells, not the gamma-delta T cells, are diminished in the spleen and blood

• the alpha-beta T cell percentage is reduced 6.23-fold and cell number is reduced 21-fold in the spleen

• similar reductions in alpha-beta T cells is seen in the thymus and bone marrow

decreased CD4-positive, alpha-beta T cell number ( J:274048 )

• percentage of CD4+ T helper cells is reduced 25.71-fold in the spleen and 58.3-fold in the blood

abnormal CD8-positive, alpha-beta cytotoxic T cell morphology ( J:274048 )

• percentage of CD8+ cytotoxic T cells is reduced 13.73-fold in the spleen and 11.16-fold in the blood

neoplasm

increased metastatic potential ( J:274048 )

• 14 days after tumor cell implantation, breast tumor cells metastasize to the lungs of mutant mice but not control mice

increased incidence of induced tumors ( J:274048 )

• mice implanted with a syngeneic tumor cell line E0771 in the 4th mammary foot pad show a faster rate of tumor growth and grow larger than in control mice implanted with tumor cells

• twice as many myeloid derived suppressor cells are present in the tumor microenvironment compared to controls

• fewer lymphoid cells are recruited to the tumor microenvironment compared to controls, with reduced CD3+CD19- T cell population due to reduced numbers of CD3+CD19-gamma-deltaTCR- alpha-beta T cells

• the tumor microenvironment shows a reduction in both CD4+ T helper cells and CD8+ cytotoxic T cell populations compared to controls

decreased tumor latency ( J:274048 )

• mice implanted with a syngeneic tumor cell line E0771 in the 4th mammary foot pad show a faster rate of tumor growth than in control mice implanted with tumor cells