Phenotypes Associated with This Genotype

Genotype
MGI:6295503

• Allelic Composition: Setd3^{tm1.1(NCOM)Mfgc}/Setd3^{tm1.1(NCOM)Mfgc}
• Genetic Background: C57BL/6N-Setd3^{tm1.1(NCOM)Mfgc}/Tcp

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

dystocia ( J:270048 )

♀ • primary dystocia in 8 of 9 female mice independent of embryo genotype

♀ • mice are refractory to oxytocin unlike wild-type mice

decreased litter size ( J:270048 )

♀ • produced from female mice

cellular

decreased cell migration ( J:270048 )

• in mouse embryonic fibroblasts

abnormal DNA methylation ( J:270048 )

• mouse embryonic fibroblasts lack actin-His73me methylation

muscle

muscle phenotype ( J:270048 )

N • muscles from young adults exhibit normal gross histopathology