Phenotypes Associated with This Genotype

Genotype
MGI:6294695

• Allelic Composition: Nsun5^em1Lgch/Nsun5^em1Lgch
• Genetic Background: involves: C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

nervous system phenotype ( J:271670 )

N • mice exhibit normal pyramidal cell density and paired-pulse ratios

abnormal dentate gyrus morphology ( J:271670 )

• fewer PDGFRalpha+ cells due to reduced proliferation of oligodendrocyte precursor cells

abnormal excitatory postsynaptic potential ( J:271670 )

• theta burst stimulation fails to increase field excitatory postsynaptic potential slopes unlike in wild-type mice

• postsynaptic potential slopes unlike in wild-type mice

• mice lack NMDAr-dependent LTP

reduced long-term potentiation ( J:271670 )

• in a 200 Hz high frequency stimulation protocol

behavior/neurological

impaired spatial learning ( J:271670 )

• in a Morris water maze

abnormal spatial working memory ( J:271670 )

• reduced alteration ratio in a Y-maze

• impaired long-term memory in a Morris water maze