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Phenotypes Associated with This Genotype
Genotype
MGI:6294293
Allelic
Composition
Tg(Prnp-HTT*82Q)8AGschi/0
Genetic
Background
involves: C3H/HeJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice live to 7-9 months of age

growth/size/body
• mice exhibit reduced weight towards the end of their life

behavior/neurological
• mice exhibit poor grooming towards the end of life
• mice exhibit hind-limb clasping when suspended by the tail towards the end of life
• by 4.5 months of age, mice show a reduction in performance on the rotarod, with a decrease in latency to fall compared to controls
• mice exhibit hunched posture towards the end of life
• 6-7 month old mice are less active than wild-type mice during the dark period

nervous system
• mice exhibit widespread nuclear inclusions of HTT in most neurons of the CNS, however no cytoplasmic inclusions are detected

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Huntington's disease DOID:12858 OMIM:143100
J:91795


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/08/2019
MGI 6.14
The Jackson Laboratory