Phenotypes Associated with This Genotype

Genotype
MGI:6287974

• Allelic Composition: Atg7^tm1Tchi/Atg7^tm1Tchi; Lyz2^tm1(cre)Ifo/Lyz2⁺; Tg(CAG-EGFP/Map1lc3b)53Nmz/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

abnormal macrophage physiology ( J:235399 )

• mice injected with UV-irradiated dying thymocytes into the spleen, liver, or kidney exhibit defective clearance of engulfed, dying cells and no induction of LC3-II, indicating failure of LC3-associated phagocytosis-dependent mechanism to degrade engulfed corpses

homeostasis/metabolism

abnormal circulating chemokine level ( J:235399 )

• serum CCL4 levels are increased in mice injected with UV-irradiated dying thymocytes

increased circulating interleukin-1 beta level ( J:235399 )

• serum IL-1beta levels are increased in mice injected with UV-irradiated dying thymocytes

decreased circulating interleukin-10 level ( J:235399 )

• serum IL-10 levels are not increased in mutant mice injected with UV-irradiated dying thymocytes like in wild-type mice

increased circulating interleukin-6 level ( J:235399 )

• serum IL-6 levels are increased in mice injected with UV-irradiated dying thymocytes

immune system

abnormal macrophage physiology ( J:235399 )

• mice injected with UV-irradiated dying thymocytes into the spleen, liver, or kidney exhibit defective clearance of engulfed, dying cells and no induction of LC3-II, indicating failure of LC3-associated phagocytosis-dependent mechanism to degrade engulfed corpses

abnormal circulating chemokine level ( J:235399 )

• serum CCL4 levels are increased in mice injected with UV-irradiated dying thymocytes

increased circulating interleukin-1 beta level ( J:235399 )

• serum IL-1beta levels are increased in mice injected with UV-irradiated dying thymocytes

decreased circulating interleukin-10 level ( J:235399 )

• serum IL-10 levels are not increased in mutant mice injected with UV-irradiated dying thymocytes like in wild-type mice

increased circulating interleukin-6 level ( J:235399 )

• serum IL-6 levels are increased in mice injected with UV-irradiated dying thymocytes