Phenotypes for Chek2 Zswim7 MGI:6287690 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Chek2^tm1Mak/Chek2^tm1Mak Zswim7^em1Mjn/Zswim7^em1Mjn
Genetic Background	involves: 129P2/OlaHsd * C57BL/6J * CBA/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chek2^tm1Mak mutation (1 available); any Chek2 mutation (52 available)
Zswim7^em1Mjn mutation (0 available); any Zswim7 mutation (12 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

reproductive system phenotype ( J:268570 )

N	• mice exhibit normal ovary weight and follicle development

oligozoospermia ( J:268570 )

decreased primordial ovarian follicle number ( J:268570 )

abnormal seminiferous tubule morphology ( J:268570 )

• improved cellularity compared with Zswim7^em1Mjn homozygotes

decreased testis weight ( J:268570 )

reduced female fertility ( J:268570 )

• reduced litter sizes

decreased litter size ( J:268570 )

• females produce reduced litters

male infertility ( J:268570 )

cellular

oligozoospermia ( J:268570 )

endocrine/exocrine glands

decreased primordial ovarian follicle number ( J:268570 )

abnormal seminiferous tubule morphology ( J:268570 )

• improved cellularity compared with Zswim7^em1Mjn homozygotes

decreased testis weight ( J:268570 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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