Phenotypes Associated with This Genotype

Genotype
MGI:6287688

• Allelic Composition: Chek2^tm1Mak/Chek2^tm1Mak; Swsap1^em1Mjn/Swsap1^em1Mjn
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * CBA/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

reproductive system phenotype ( J:268570 )

♀N • mice exhibit normal ovary weight and follicle development

decreased oocyte number ( J:268570 )

♀ • marginally

oligozoospermia ( J:268570 )

♂

abnormal chromosomal synapsis ( J:268570 )

♀ • with reduced MLH1 focus numbers

decreased primordial ovarian follicle number ( J:268570 )

♀

abnormal seminiferous tubule morphology ( J:268570 )

♂ • improved cellularity compared with Zswim7^em1Mjn homozygotes

decreased testis weight ( J:268570 )

♂

impaired embryo implantation ( J:268570 )

♀ • marginally

reduced female fertility ( J:268570 )

♀ • reduced litter sizes

decreased litter size ( J:268570 )

♀ • females produce reduced litters

male infertility ( J:268570 )

♂

cellular

decreased oocyte number ( J:268570 )

♀ • marginally

oligozoospermia ( J:268570 )

♂

abnormal chromosomal synapsis ( J:268570 )

♀ • with reduced MLH1 focus numbers

endocrine/exocrine glands

decreased primordial ovarian follicle number ( J:268570 )

♀

abnormal seminiferous tubule morphology ( J:268570 )

♂ • improved cellularity compared with Zswim7^em1Mjn homozygotes

decreased testis weight ( J:268570 )

♂