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Phenotypes Associated with This Genotype
Genotype
MGI:6287207
Allelic
Composition
Arhgef10tm1.1Ssfg/Arhgef10tm1.1Ssfg
Genetic
Background
B6.129S1-Arhgef10tm1.1Ssfg
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Arhgef10tm1.1Ssfg mutation (0 available); any Arhgef10 mutation (69 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
N
• mice have a normal startle reflex response and show normal spatial learning in the Morris water maze test and no obvious impulsive behaviors in the electro-foot shock aversive water drinking test (EFSDT)
• in the tail suspension and forced swim tests, mice exhibit significantly decreased immobility time relative to wild-type controls, indicating reduced depression-related behavior
• in the elevated plus maze test, mice spend significantly more time in the open arms than wild-type controls, indicating reduced anxiety-like behavior
• in the open field test, mice show significantly increased spontaneous locomotor activity relative to wild-type controls
• however, rearing activity and percent of activity in the center of the open field are normal
• in the 3-chamber paradigm, mice exhibit social impairment, as they fail to spend a significantly longer time in the chamber with a stranger mouse 1 than in the empty chamber and show equal active interaction time in the chamber with the empty cylinder and stranger 1, unlike wild-type controls
• in the preference for social novelty test, mice spend less time in the chamber with a novel mouse stranger 2 than in the chamber with stranger 1 and the time spent in social interactions is similar between the stranger mouse 1 and 2, unlike in wild-type controls

homeostasis/metabolism
• mice show significantly increased dopamine levels in the striatum and amygdala
• however, 3,4-Dihydroxyphenylacetic acid (DOPAC) levels are normal
• mice show significantly increased norepinephrine (NE) levels in the frontal cortex and amygdala
• mice show significantly increased serotonin (5-HT) levels in the frontal cortex and amygdala
• however, 5-hydroxyindoleacetic acid (5-HIAA) levels are normal
• protein levels of monoamine oxidase A (MAO-A) are significantly decreased in the frontal cortex and amygdala

nervous system
N
• mice exhibit no deficit in pre-pulse inhibition (PPI) relative to wild-type controls

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
autism spectrum disorder DOID:0060041 J:271943


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory