Phenotypes Associated with This Genotype

Genotype
MGI:6287141

• Allelic Composition: Cd96^tm1.1Mjs/Cd96^tm1.1Mjs
• Genetic Background: B6.129P2(Cg)-Cd96^tm1.1Mjs

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:209990 )

N • normal development of lymphoid organs

abnormal NK cell physiology ( J:209990 )

• significantly increased proportion of Ifng+ NK cells in spleen after LPS-induced endotoxicosis

• normal Ifng production by NK cells in response to Il12 and Il18 stimulation in vitro

increased inflammatory response ( J:209990 )

• increased levels of serum Ifng, Il1a, and Il1b after LPS-induced endotoxicosis at 0.5 mg LPS/30 g level

• normal levels of serum Tnf, Il12 and Il6 after LPS-induced endotoxicosis at 0.5 mg LPS/30 g level

increased susceptibility to endotoxin shock ( J:209990 )

• significantly reduced survival rates after LPS-induced endotoxicosis at 0.5 or 0.25 mg LPS/30 g levels

neoplasm

decreased incidence of tumors by chemical induction ( J:209990 )

• increased resistance to 3'-methylcholanthrene (MCA)-induced formation of fibrosarcomas, esp. at doses of 100 ug and 400 ug

decreased metastatic potential ( J:209990 )

• fewer lung metastases after injection of B16F10 melanoma cells into tail vein

hematopoietic system

hematopoietic system phenotype ( J:209990 )

N • normal development of lymphoid organs

abnormal NK cell physiology ( J:209990 )

• significantly increased proportion of Ifng+ NK cells in spleen after LPS-induced endotoxicosis

• normal Ifng production by NK cells in response to Il12 and Il18 stimulation in vitro

homeostasis/metabolism

decreased incidence of tumors by chemical induction ( J:209990 )

• increased resistance to 3'-methylcholanthrene (MCA)-induced formation of fibrosarcomas, esp. at doses of 100 ug and 400 ug

endocrine/exocrine glands

endocrine/exocrine gland phenotype ( J:209990 )

N • normal development of lymphoid organs

embryo

embryo phenotype ( J:209990 )

N • mice are born at expected Mendelian ratio