Phenotypes Associated with This Genotype

Genotype
MGI:6286688

• Allelic Composition: Tg(Prnp-Immt/SOD1*G93A)7Gmnf/0
• Genetic Background: involves: C57BL/6 * CBA * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

decreased body weight ( J:177846 )

cellular

abnormal mitochondrial morphology ( J:177846 )

• mitochondria exhibit cristae disorganization, swelling, and vacuolization in spinal cord neurons and sciatic nerve at 12 months of age

disorganized mitochondrial cristae ( J:177846 )

• mitochondria exhibit cristae disorganization in spinal cord neurons and sciatic nerve of 12 month old mice

behavior/neurological

behavior/neurological phenotype ( J:177846 )

N • mice exhibit normal motor competence on the accelerating rotarod from 2 months to 18 months of age

nervous system

nervous system phenotype ( J:177846 )

N • mice do not exhibit changes in motor neuron counts in the lumbar spinal cord at 12 months of age