Phenotypes Associated with This Genotype

Genotype
MGI:6286405

• Allelic Composition: Del(6Gimap5-Gimap3)1Yout/Del(6Gimap5-Gimap3)1Yout
• Genetic Background: involves: C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

endocrine/exocrine gland phenotype ( J:209926 )

N • normal thymocyte cellularity

hematopoietic system

decreased B cell number ( J:209926 )

• decrease in B cell numbers in spleen and lymph nodes

decreased NK cell number ( J:209926 )

• severe reduction in DX5+ NK1.1+ cells in spleen

decreased T cell number ( J:209926 )

• decrease in NK1.1+ CD3-, NK1.1+ CD3+, CD4+, and CD8+ T cell numbers in spleen and lymph nodes

• decrease in TCRalphabeta and TCRgammadelta lineage intestinal intraepithelial T cells

• reduced unstimulated CD8+ T cell survival in vitro

• severely reduced anti-CD3 and anti-CD28 stimulated survival of CD4+ and CD8+ T cells in vitro

• normal Il7-stimulated survival of T cells in vitro

abnormal T cell physiology ( J:209926 )

• altered expression of CD44 and CD62L in CD4+ T cells and CD8+ T cells in spleen

• enrichment of CD122high CD124high cells in spleen

• normal expression of CD5, CD25, CD28, CD69, CD127, and CD132 in CD4+ T cells and CD8+ T cells in spleen

immune system

decreased B cell number ( J:209926 )

• decrease in B cell numbers in spleen and lymph nodes

decreased NK cell number ( J:209926 )

• severe reduction in DX5+ NK1.1+ cells in spleen

decreased T cell number ( J:209926 )

• decrease in NK1.1+ CD3-, NK1.1+ CD3+, CD4+, and CD8+ T cell numbers in spleen and lymph nodes

• decrease in TCRalphabeta and TCRgammadelta lineage intestinal intraepithelial T cells

• reduced unstimulated CD8+ T cell survival in vitro

• severely reduced anti-CD3 and anti-CD28 stimulated survival of CD4+ and CD8+ T cells in vitro

• normal Il7-stimulated survival of T cells in vitro

abnormal T cell physiology ( J:209926 )

• altered expression of CD44 and CD62L in CD4+ T cells and CD8+ T cells in spleen

• enrichment of CD122high CD124high cells in spleen

• normal expression of CD5, CD25, CD28, CD69, CD127, and CD132 in CD4+ T cells and CD8+ T cells in spleen