Phenotypes Associated with This Genotype

Genotype
MGI:6286327

• Allelic Composition: Ctsl^m1Btlr/Ctsl^m1Btlr
• Genetic Background: C57BL/6J-Ctsl^m1Btlr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal T cell differentiation ( J:272869 )

• increased CD44 expression on peripheral blood CD4+ T cells

• increased CD44 expression on peripheral blood CD8+ T cells

abnormal CD4-positive T cell differentiation ( J:272869 )

• increased CD44 expression on peripheral blood CD4+ T cells

abnormal CD8-positive, alpha-beta T cell differentiation ( J:272869 )

• increased CD44 expression on peripheral blood CD8+ T cells

decreased alpha-beta T cell number ( J:272869 )

• reduced frequencies of T cells in the peripheral blood

• decreased peripheral blood CD4 to CD8 T cell ratios

decreased CD4-positive, alpha-beta T cell number ( J:272869 )

• reduced frequencies of CD4+ T cells and CD4+ T cells in CD3+ T cells

• reduced frequencies of naive CD4 T cells in CD4 T cells in the peripheral blood

increased alpha-beta T cell number ( J:272869 )

• increased frequencies of CD44+ T cells in the peripheral blood

increased central memory CD4-positive, alpha-beta T cell number ( J:272869 )

• increased frequencies of central memory CD4 T cells in CD4 T cells in the peripheral blood

increased effector memory CD4-positive, alpha-beta T cell number ( J:272869 )

• increased frequencies of effector memory CD4 T cells in CD4 T cells in the peripheral bloo

increased CD8-positive, alpha-beta T cell number ( J:272869 )

• increased frequency of CD8+ T cells and CD8+ T cells in CD3+ T cells in the peripheral blood

increased central memory CD8 positive, alpha-beta T cell number ( J:272869 )

• increased frequencies of central memory CD8 T cells in CD8 T cells in the peripheral blood

abnormal CD8-positive, alpha beta T cell morphology ( J:272869 )

• increased frequencies of CD44+ CD8 T cells in the peripheral blood

integument

alopecia ( J:272869 )

• sparse hair growth and/or alopecia all over their bodies

hematopoietic system

abnormal T cell differentiation ( J:272869 )

• increased CD44 expression on peripheral blood CD4+ T cells

• increased CD44 expression on peripheral blood CD8+ T cells

abnormal CD4-positive T cell differentiation ( J:272869 )

• increased CD44 expression on peripheral blood CD4+ T cells

abnormal CD8-positive, alpha-beta T cell differentiation ( J:272869 )

• increased CD44 expression on peripheral blood CD8+ T cells

decreased alpha-beta T cell number ( J:272869 )

• reduced frequencies of T cells in the peripheral blood

• decreased peripheral blood CD4 to CD8 T cell ratios

decreased CD4-positive, alpha-beta T cell number ( J:272869 )

• reduced frequencies of CD4+ T cells and CD4+ T cells in CD3+ T cells

• reduced frequencies of naive CD4 T cells in CD4 T cells in the peripheral blood

increased alpha-beta T cell number ( J:272869 )

• increased frequencies of CD44+ T cells in the peripheral blood

increased central memory CD4-positive, alpha-beta T cell number ( J:272869 )

• increased frequencies of central memory CD4 T cells in CD4 T cells in the peripheral blood

increased effector memory CD4-positive, alpha-beta T cell number ( J:272869 )

• increased frequencies of effector memory CD4 T cells in CD4 T cells in the peripheral bloo

increased CD8-positive, alpha-beta T cell number ( J:272869 )

• increased frequency of CD8+ T cells and CD8+ T cells in CD3+ T cells in the peripheral blood

increased central memory CD8 positive, alpha-beta T cell number ( J:272869 )

• increased frequencies of central memory CD8 T cells in CD8 T cells in the peripheral blood

abnormal CD8-positive, alpha beta T cell morphology ( J:272869 )

• increased frequencies of CD44+ CD8 T cells in the peripheral blood