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Phenotypes Associated with This Genotype
Genotype
MGI:6285638
Allelic
Composition		 Stk4m5Btlr/Stk4m5Btlr
Genetic
Background		 C57BL/6J-Stk4m5Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stk4m5Btlr mutation (0 available); any Stk4 mutation (72 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal T cell differentiation ( J:272743 )
• increased CD44 expression on peripheral blood T cells
abnormal CD4-positive T cell differentiation ( J:272743 )
• increased CD44 expression on CD4+ T cells
increased central memory CD4-positive, alpha-beta T cell number ( J:272743 )
• increased frequencies of central memory CD4 T cells in CD4 T cells in the peripheral blood
decreased CD4-positive, alpha-beta T cell number ( J:272743 )
• reduced frequencies of naive CD4 T cells in CD4 T cells in the peripheral blood

hematopoietic system
abnormal T cell differentiation ( J:272743 )
• increased CD44 expression on peripheral blood T cells
abnormal CD4-positive T cell differentiation ( J:272743 )
• increased CD44 expression on CD4+ T cells
increased central memory CD4-positive, alpha-beta T cell number ( J:272743 )
• increased frequencies of central memory CD4 T cells in CD4 T cells in the peripheral blood
decreased CD4-positive, alpha-beta T cell number ( J:272743 )
• reduced frequencies of naive CD4 T cells in CD4 T cells in the peripheral blood

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory