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Phenotypes Associated with This Genotype
Genotype
MGI:6285560
Allelic
Composition		 Stk4m4Btlr/Stk4m4Btlr
Genetic
Background		 C57BL/6J-Stk4m4Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stk4m4Btlr mutation (0 available); any Stk4 mutation (72 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased CD11b-high dendritic cell number ( J:272536 )
• reduced frequency of CD11b+dendritic cells (DCs) gated in CD11c+cells in the peripheral blood
increased dendritic cell number ( J:272536 )
• increased frequencies of CD8a+ dendritic cells (gated in CD11c+ cells) in the peripheral blood
increased B-1b cell number ( J:272536 )
• increased frequencies of B1b cells in B1 cells in the peripheral blood
decreased IgD level ( J:272536 )
• reduced IgD expression on peripheral blood B cells
decreased IgG level ( J:272536 )
• the T-dependent antibody response to recombinant Semliki Forest virus (rSFV)-encoded beta-galactosidase (rSFV-beta-gal) was diminished
impaired humoral immune response ( J:272536 )
• the T-dependent antibody response to recombinant Semliki Forest virus (rSFV)-encoded beta-galactosidase (rSFV-beta-gal) was diminished

hematopoietic system
decreased CD11b-high dendritic cell number ( J:272536 )
• reduced frequency of CD11b+dendritic cells (DCs) gated in CD11c+cells in the peripheral blood
increased dendritic cell number ( J:272536 )
• increased frequencies of CD8a+ dendritic cells (gated in CD11c+ cells) in the peripheral blood
increased B-1b cell number ( J:272536 )
• increased frequencies of B1b cells in B1 cells in the peripheral blood
decreased IgD level ( J:272536 )
• reduced IgD expression on peripheral blood B cells
decreased IgG level ( J:272536 )
• the T-dependent antibody response to recombinant Semliki Forest virus (rSFV)-encoded beta-galactosidase (rSFV-beta-gal) was diminished

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory