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Phenotypes Associated with This Genotype
Genotype
MGI:6284809
Allelic
Composition		 Jak3m6Btlr/Jak3m6Btlr
Genetic
Background		 C57BL/6J-Jak3m6Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Jak3m6Btlr mutation (0 available); any Jak3 mutation (84 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased CD4-positive, alpha-beta T cell number ( J:272400 )
• increased frequencies of CD4+ T cells in CD3+ T cells
decreased CD8-positive, alpha-beta T cell number ( J:272400 )
• reduced frequencies of CD8+ T cells in CD3+ T cells
decreased IgG level ( J:272400 )
• the T-dependent antibody response to ovalbumin administered with aluminum hydroxide was also diminished
impaired humoral immune response ( J:272400 )
• the T-dependent antibody response to ovalbumin administered with aluminum hydroxide was also diminished

hematopoietic system
increased CD4-positive, alpha-beta T cell number ( J:272400 )
• increased frequencies of CD4+ T cells in CD3+ T cells
decreased CD8-positive, alpha-beta T cell number ( J:272400 )
• reduced frequencies of CD8+ T cells in CD3+ T cells
decreased IgG level ( J:272400 )
• the T-dependent antibody response to ovalbumin administered with aluminum hydroxide was also diminished

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory