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Phenotypes Associated with This Genotype
Genotype
MGI:6283877
Allelic
Composition		 Rag1m4Btlr/Rag1m4Btlr
Genetic
Background		 C57BL/6J-Rag1m4Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rag1m4Btlr mutation (0 available); any Rag1 mutation (133 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal T cell differentiation ( J:272094 )
• CD44 expression was increased on peripheral blood T cells
abnormal CD8-positive, alpha-beta T cell differentiation ( J:272094 )
• CD44 expression was increased on peripheral blood CD8+ T cells
decreased B cell number ( J:272094 )
• reduced frequencies of B cells in the peripheral blood
decreased CD8-positive, naive alpha-beta T cell number ( J:272094 )
• reduced frequencies of naive CD8 T cells in the peripheral blood
increased alpha-beta T cell number ( J:272094 )
• increased frequencies of CD44+ T cells in the peripheral blood
increased CD8-positive, alpha-beta T cell number ( J:272094 )
• increased frequencies of CD44+ CD8 T cells in the peripheral blood
increased central memory CD8 positive, alpha-beta T cell number ( J:272094 )
• increased frequencies of central memory CD8 T cells in the peripheral blood

hematopoietic system
abnormal T cell differentiation ( J:272094 )
• CD44 expression was increased on peripheral blood T cells
abnormal CD8-positive, alpha-beta T cell differentiation ( J:272094 )
• CD44 expression was increased on peripheral blood CD8+ T cells
decreased B cell number ( J:272094 )
• reduced frequencies of B cells in the peripheral blood
decreased CD8-positive, naive alpha-beta T cell number ( J:272094 )
• reduced frequencies of naive CD8 T cells in the peripheral blood
increased alpha-beta T cell number ( J:272094 )
• increased frequencies of CD44+ T cells in the peripheral blood
increased CD8-positive, alpha-beta T cell number ( J:272094 )
• increased frequencies of CD44+ CD8 T cells in the peripheral blood
increased central memory CD8 positive, alpha-beta T cell number ( J:272094 )
• increased frequencies of central memory CD8 T cells in the peripheral blood

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/20/2026
MGI 6.24 		The Jackson Laboratory