Phenotypes Associated with This Genotype

Genotype
MGI:6283504

• Allelic Composition: Elmo1^M4Btlr/Elmo1^M4Btlr
• Genetic Background: C57BL/6J-Elmo1^M4Btlr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

abnormal B cell morphology ( J:271969 )

• reduced peripheral blood B to T cell ratios

increased B-1 B cell number ( J:271969 )

• increased frequencies of B1 cells in the peripheral blood

abnormal T cell morphology ( J:271969 )

• reduced peripheral blood B to T cell ratios

• reduced peripheral blood CD4+to CD8+T cell ratios

decreased CD4-positive, alpha-beta T cell number ( J:271969 )

• reduced frequencies of CD4+T cells in CD3+T cells in the peripheral blood

increased CD8-positive, alpha-beta T cell number ( J:271969 )

• increased frequencies of CD8+T cells and CD8+T cells in CD3+T cells in the peripheral blood

immune system

abnormal B cell morphology ( J:271969 )

• reduced peripheral blood B to T cell ratios

increased B-1 B cell number ( J:271969 )

• increased frequencies of B1 cells in the peripheral blood

abnormal T cell morphology ( J:271969 )

• reduced peripheral blood B to T cell ratios

• reduced peripheral blood CD4+to CD8+T cell ratios

decreased CD4-positive, alpha-beta T cell number ( J:271969 )

• reduced frequencies of CD4+T cells in CD3+T cells in the peripheral blood

increased CD8-positive, alpha-beta T cell number ( J:271969 )

• increased frequencies of CD8+T cells and CD8+T cells in CD3+T cells in the peripheral blood