Phenotypes Associated with This Genotype

Genotype
MGI:6283499

• Allelic Composition: Svep1^{tm1a(EUCOMM)Hmgu}/Svep1^{tm1a(EUCOMM)Hmgu}
• Genetic Background: involves: C57BL/6N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

nuchal edema ( J:244466 )

• at E18.5

lymphedema ( J:244466 )

• at E14.5 or later, homozygotes exhibit edema formation of variable severity; some only display edema at the dorsal side while others also have edema at the ventral side

• by E18.5, all homozygotes display mild or severe edema

immune system

abnormal lymphatic vessel morphology ( J:244466 )

• at E18.5, mesenteric lymphatic vessels are significantly smaller in size, appear non-luminized, lack lymphatic valve structures, and retain higher levels of VEGFR-3, CD31, and Prox-1 expression

abnormal lymphangiogenesis ( J:244466 )

• at E12.5, the first lymphovenous contact site is abnormally formed: Prox-1+ cells of the cardinal vein and Prox-1+ lymphatic endothelial cells fail to come together in tight association, and no accumulation of Prox-1/Vegfr-3+ cells occurs at the lymphovenous connection site, unlike in wild-type embryos

• at E13.5, the tight association of lymphatic and venous endothelium (typical of the site of prospective valve formation) is missing, unlike in wild-type embryos

• at E18.5, mesenteric lymphatic structures fail to undergo remodeling events and show absence of lymphatic valve formation

integument

nuchal edema ( J:244466 )

• at E18.5

growth/size/body

nuchal edema ( J:244466 )

• at E18.5