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Phenotypes Associated with This Genotype
Genotype
MGI:6279290
Allelic
Composition		 Pdcd10tm1Kwhi/Pdcd10tm1Kwhi
Nfatc1tm1.1(cre)Bz/Nfatc1+
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nfatc1tm1.1(cre)Bz mutation (0 available); any Nfatc1 mutation (47 available)
Pdcd10tm1Kwhi mutation (0 available); any Pdcd10 mutation (18 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
lethality throughout fetal growth and development, complete penetrance ( J:238897 )
• embryonic lethality, with all fetuses dead by E15.5-E17.5

cardiovascular system
thin myocardium ( J:238897 )
• embryos exhibit a reduction in myocardial growth at E12.5
abnormal cardiac jelly morphology ( J:238897 )
• embryos exhibit reduced cardiac jelly at E12.5 as indicated by reduced matrix glycosaminoglycans and versican in the heart

muscle
thin myocardium ( J:238897 )
• embryos exhibit a reduction in myocardial growth at E12.5

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory