Phenotypes for Ccm2 Nfatc1 MGI:6279289 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Ccm2^tm1Mlkn/Ccm2^tm1Mlkn Nfatc1^tm1.1(cre)Bz/Nfatc1⁺
Genetic Background	involves: 129 * 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccm2^tm1Mlkn mutation (0 available); any Ccm2 mutation (46 available)
Nfatc1^tm1.1(cre)Bz mutation (0 available); any Nfatc1 mutation (50 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:238897 )

• embryonic lethality at E14.5-E15.5

cardiovascular system

thin myocardium ( J:238897 )

• embryos exhibit a reduction in myocardial growth at E10.5

decreased cardiac jelly amount ( J:238897 )

• embryos exhibit a reduction in cardiac jelly at E10.5 as indicated by reduced matrix glycosaminoglycans and versican in the heart

muscle

thin myocardium ( J:238897 )

• embryos exhibit a reduction in myocardial growth at E10.5

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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