Phenotypes Associated with This Genotype

Genotype
MGI:6278108

• Allelic Composition: Chchd4^{Gt(IST11943B12)Tigm}/Chchd4^{Gt(IST11943B12)Tigm}
• Genetic Background: involves: C57BL/6N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality between implantation and placentation, complete penetrance ( J:256078 )

• homozygous embryos exhibit a developmental arrest coupled with embryonic lethality at the onset of gastrulation, with no embryos detected after E8.5

embryo

embryonic growth arrest ( J:256078 )

• homozygous embryos exhibit a developmental arrest at the onset of gastrulation

embryonic growth retardation ( J:256078 )

growth/size/body

embryonic growth retardation ( J:256078 )

cellular

abnormal mitochondrial ATP synthesis coupled electron transport ( J:256078 )

• at E5.5-E6, homozygous embryos show a major defect in the expression of respiratory chain complex I subunit CI-20