Phenotypes Associated with This Genotype

Genotype
MGI:6277904

• Allelic Composition: Mpz^tm1Msch/Mpz^tm1Msch; Tg(Mpz)88.4Mfel/0
• Genetic Background: FVB.Cg-Mpz^tm1Msch Tg(Mpz)88.4Mfel

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal myelin sheath morphology ( J:77658 )

• abnormal compaction is not improved

• two types of abnormally compacted fibers are seen: rare fibers in which both the intraperiod and major dense line are absent and majority of fibers with myelin that appears compacted but has abnormal periodicity due to a wide (but not absent) intraperiod line

decreased myelin sheath thickness ( J:77658 )

• myelin sheaths are thinner

tomacula ( J:77658 )

• tomacular are readily seen at P28

• tomacula are not improved and are worsened

dysmyelination ( J:77658 )

• hypomyelination is only slightly improved