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Phenotypes Associated with This Genotype
Genotype
MGI:6276671
Allelic
Composition
Tg(Mpz)88.4Mfel/0
Genetic
Background
FVB/N-Tg(Mpz)88.4Mfel
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological

muscle
• mice exhibit variable signs of muscle weakness such as clenching of the apws, dragging of hind limbs and floppy tail
• symptoms are least severe in this line

nervous system
• sciatic nerves show uncompaction of the myelin sheath
• sciatic nerves show tomacula
• sciatic nerves show hypomyelination

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Charcot-Marie-Tooth disease type 1B DOID:0110152 OMIM:118200
J:77658


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/23/2021
MGI 6.16
The Jackson Laboratory