Phenotypes Associated with This Genotype

Genotype
MGI:6272627

• Allelic Composition: Smcr8^em1Btlr/Smcr8^em1Btlr
• Genetic Background: C57BL/6J-Smcr8^em1Btlr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

increased circulating interleukin-12b level ( J:268243 )

• at 9 months of age

immune system

increased susceptibility to induced colitis ( J:268243 )

• dextran sulfate sodium (DSS)-induced

enlarged spleen ( J:268243 )

• at 12 months of age

increased CD4-positive, alpha-beta T cell number ( J:268243 )

• increased frequency of activated Cd4+ (CD44+CD62L CD4+) T cells in the peripheral blood

increased CD8-positive, alpha-beta T cell number ( J:268243 )

• increased frequency of activated Cd4+ (CD44+CD62L CD8+) T cells in the peripheral blood

increased circulating interleukin-12b level ( J:268243 )

• at 9 months of age

enlarged lymph nodes ( J:268243 )

• at 12 months of age

increased interleukin-6 secretion ( J:268243 )

• in response to the TLR9 ligand CpG, TLR3 ligand poly(I:C), and the TLR7 ligand R848

increased tumor necrosis factor secretion ( J:268243 )

• in response to the TLR9 ligand CpG, TLR3 ligand poly(I:C), and the TLR7 ligand R848

digestive/alimentary system

increased susceptibility to induced colitis ( J:268243 )

• dextran sulfate sodium (DSS)-induced

cellular

abnormal lysosome morphology ( J:268243 )

• accumulation in macrophages

abnormal lysosome physiology ( J:268243 )

• impaired acidification of the phagolysosome in macrophages

hematopoietic system

enlarged spleen ( J:268243 )

• at 12 months of age

increased CD4-positive, alpha-beta T cell number ( J:268243 )

• increased frequency of activated Cd4+ (CD44+CD62L CD4+) T cells in the peripheral blood

increased CD8-positive, alpha-beta T cell number ( J:268243 )

• increased frequency of activated Cd4+ (CD44+CD62L CD8+) T cells in the peripheral blood

growth/size/body

enlarged spleen ( J:268243 )

• at 12 months of age