Phenotypes Associated with This Genotype

Genotype
MGI:6272590

• Allelic Composition: Tg(Dct-lacZ)A12Jkn/0; Tg(Tyr-Ctnnb1/EGFP)#Lru/0
• Genetic Background: B6.Cg-Tg(Tyr-Ctnnb1/EGFP)#Lru Tg(Dct-lacZ)A12Jkn

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

embryo

decreased melanoblast proliferation ( J:176245 )

• overall, melanoblasts exhibit a lower level of BrdU incorporation in the epidermis (E12.5 to E14.5) and dermis (E13.5) relative to wild-type controls

• however, no differences in apoptosis, cell differentiation or fate are observed

abnormal melanoblast morphology ( J:176245 )

• in the trunk region, melanoblast number is normal at E10.5 but significantly lower than that in wild-type controls at each developmental stage from E11.5 to E15.5; this difference increases with time

• although melanoblast numbers are reduced in both the epidermis and dermis, the reduction is far greater in the epidermis than in the dermis

cellular

decreased melanoblast proliferation ( J:176245 )

• overall, melanoblasts exhibit a lower level of BrdU incorporation in the epidermis (E12.5 to E14.5) and dermis (E13.5) relative to wild-type controls

• however, no differences in apoptosis, cell differentiation or fate are observed

nervous system

abnormal melanoblast morphology ( J:176245 )

• in the trunk region, melanoblast number is normal at E10.5 but significantly lower than that in wild-type controls at each developmental stage from E11.5 to E15.5; this difference increases with time

• although melanoblast numbers are reduced in both the epidermis and dermis, the reduction is far greater in the epidermis than in the dermis