Phenotypes for Bcl2a1a Bcl2a1b Bcl2a1d MGI:6272387 MGI Mouse

immune system phenotype ( J:258915 )

N	• no defects in the B lymphocyte lineage • normal T cell development with no changes in DN1-4 thymocytes, immature double positive thymocytes or mature CD4+ or CD8+ populations

decreased dendritic cell number ( J:258915 )

• reduction in conventional dendritic cells (both CD11b+ and CD8+) in the spleen

• decrease in the number of effector memory (CD62L^lo CD44+) cells

• decrease in the number of effector memory (CD62L^lo CD44+) cells

• small but significant decrease

• decrease in the proportion of FOXP3+ regulatory T cells in the thymus and spleen, although the total number is only decreased in the spleen

• impaired survival of conventional dendritic cells in culture

decreased dendritic cell number ( J:258915 )

• reduction in conventional dendritic cells (both CD11b+ and CD8+) in the spleen

• decrease in the number of effector memory (CD62L^lo CD44+) cells

• decrease in the number of effector memory (CD62L^lo CD44+) cells

• small but significant decrease

• decrease in the proportion of FOXP3+ regulatory T cells in the thymus and spleen, although the total number is only decreased in the spleen

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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