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Phenotypes Associated with This Genotype
Genotype
MGI:6272014
Allelic
Composition
Tnni2tm1Sgao/Tnni2tm1Sgao
Genetic
Background
involves: 129 * ICR
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tnni2tm1Sgao mutation (0 available); any Tnni2 mutation (8 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• nearly all mice die within hours of birth with few surviving to weaning

skeleton
• at E14.75 with shortened primary centers of ossification
• at E14.75 with shortened primary centers of ossification
• at E14.75 with shortened primary centers of ossification
• at E14.75 with shortened primary centers of ossification
• reduced recruitment of blood vessels into the cartilage plate of the radii and ulnae at E15.5
• of the cranium at E16.5, P2 and P5
• reduced matrix mineralization in the radii at P1
• reduced cranium mineralization at E16.5, P2 and P5

growth/size/body

limbs/digits/tail
• at E14.75 with shortened primary centers of ossification
• at E14.75 with shortened primary centers of ossification
• at E14.75 with shortened primary centers of ossification


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
01/07/2020
MGI 6.14
The Jackson Laboratory