Phenotypes Associated with This Genotype

Genotype
MGI:6270457

• Allelic Composition: Tg(Comp-tTA)#Yeli/0; Tg(tetO-DDR2)#Yeli/0
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

increased susceptibility to injury ( J:176308 )

• mice subjected to destabilization of the medial meniscus (DMM) surgery at 2 months after doxycycline removal show accelerated progression of articular cartilage degeneration in the knee joints

immune system

osteoarthritis ( J:176308 )

• mice subjected to destabilization of the medial meniscus (DMM) surgery at 2 months after doxycycline removal show accelerated progression of articular cartilage degeneration in the knee joints and show more degraded collagen type II at 12 weeks after DMM surgery

• however, under normal conditions knee joints appear normal and mice do not show signs of early onset articular cartilage degeneration following doxycycline removal

skeleton

osteoarthritis ( J:176308 )

• mice subjected to destabilization of the medial meniscus (DMM) surgery at 2 months after doxycycline removal show accelerated progression of articular cartilage degeneration in the knee joints and show more degraded collagen type II at 12 weeks after DMM surgery

• however, under normal conditions knee joints appear normal and mice do not show signs of early onset articular cartilage degeneration following doxycycline removal