Phenotypes Associated with This Genotype

Genotype
MGI:6269451

• Allelic Composition: Mc1r^tm1.1Mymi/Mc1r^tm1.1Mymi; Tg(KRT14-rtTA)F42Efu/0; Tg(tetO-EDN1,-lacZ)9Mhus/0; Tg(Tyr-cre/ERT2)13Bos/0
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NTac * FVB

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

pigmentation

abnormal epidermal melanocyte morphology ( J:231435 )

• following wounding, mice show a significant increase of epidermal melanocytes containing dark pigment in the wound site, indicating that Edn1 overexpression in epithelial cells can rescue the defect of epidermal melanocyte regeneration caused by MC1R loss in the melanocyte lineage

integument

abnormal epidermal melanocyte morphology ( J:231435 )

• following wounding, mice show a significant increase of epidermal melanocytes containing dark pigment in the wound site, indicating that Edn1 overexpression in epithelial cells can rescue the defect of epidermal melanocyte regeneration caused by MC1R loss in the melanocyte lineage