Phenotypes for Gsdmd MGI:6268772 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Gsdmd^m1Btlr/Gsdmd^m1Btlr
Genetic Background	C57BL/6J-Gsdmd^m1Btlr

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Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gsdmd^m1Btlr mutation (0 available); any Gsdmd mutation (35 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased interleukin-1 beta secretion ( J:267555 )

• in response to priming with lipopolysaccharide (LPS) followed byflagellin treatment (NLRC4 inflammasome) or nigericin treatment (NLRP3 inflammasome)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/30/2025 MGI 6.24